The Sacklers have become one of the world's most controversial families.
They are the owners of Purdue Pharma, a pharmaceutical company that produces the opioid painkiller OxyContin.
As a result, the family has been accused of fuelling a deadly opioid crisis in the US that has killed more than 200,000 people in two decades.
Purdue and the Sacklers have denied allegations in lawsuits that they contributed to the opioid crisis, and have pointed to heroin and fentanyl as more significant culprits than prescription painkillers.
The family has also long been known for philanthropy, with museum wings, galleries and even escalators across the world named after them.
On Sunday Purdue Pharma filed for bankruptcy protection, as part of the company's efforts to deal with the thousands of lawsuits it is facing in connection with the opioid crisis.
Last week, the firm had reached a tentative deal to settle most of those lawsuits.
So who are the Sacklers, and what is the scale of the opioid crisis?